Retrogenesis: clinical, physiologic, and pathologic mechanisms in brain aging, Alzheimer’s and other dementing processes

  title={Retrogenesis: clinical, physiologic, and pathologic mechanisms in brain aging, Alzheimer’s and other dementing processes},
  author={Barry Reisberg and Emile H. Franssen and Syed Mahmood Hasan and Isabel Monteiro and Istvan Boksay and Lidu{\"i}n E.M. Souren and Sunnie Kenowsky and Stefanie R. Auer and Shahid Elahi and Alan Kluger},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
Abstract Data from clinical, electrophysiologic, neurophysiologic, neuroimaging and neuropathologic sources indicates that the progression of brain aging and Alzheimer’s disease (AD) deterioration proceeds inversely to human ontogenic acquisition patterns. A word for this process of degenerative developmental recapitulation, “retrogenesis”, has been proposed. These retrogenic processes provide new insights into the pathologic mechanism of AD deterioration. An understanding of retrogenic… 
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