Retrogenesis: clinical, physiologic, and pathologic mechanisms in brain aging, Alzheimer’s and other dementing processes

@article{Reisberg1999RetrogenesisCP,
  title={Retrogenesis: clinical, physiologic, and pathologic mechanisms in brain aging, Alzheimer’s and other dementing processes},
  author={Barry Reisberg and Emile H. Franssen and Syed Mahmood Hasan and Isabel Monteiro and Istvan Boksay and Lidu{\"i}n E.M. Souren and Sunnie Kenowsky and Stefanie R. Auer and Shahid Elahi and Alan Kluger},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
  year={1999},
  volume={249},
  pages={S28-S36}
}
Abstract Data from clinical, electrophysiologic, neurophysiologic, neuroimaging and neuropathologic sources indicates that the progression of brain aging and Alzheimer’s disease (AD) deterioration proceeds inversely to human ontogenic acquisition patterns. A word for this process of degenerative developmental recapitulation, “retrogenesis”, has been proposed. These retrogenic processes provide new insights into the pathologic mechanism of AD deterioration. An understanding of retrogenic… 
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163 Citations
Highly Influential Citations
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163 Citations

Alzheimer’s disease: Pathogenesis and prevention
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The Rubial-Alvarez et al. analysis supports the concept that the general pattern of childhood development is approximately recapitulated in reverse order by the pattern of deterioration associated with the continuum of AD progression from normal adult cognition through “mild cognitive impairment” and the stages of dementia to the most profound, complete state.
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The researches of myelin breakdown may provide novel diagnostic biomarkers and targets in the early diagnosis and treatment in AD.
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References

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