Retroendocytosis of high density lipoproteins by the human hepatoma cell line, HepG2.

@article{Kambouris1990RetroendocytosisOH,
  title={Retroendocytosis of high density lipoproteins by the human hepatoma cell line, HepG2.},
  author={A M Kambouris and Paul Daniel Roach and G Dennis Calvert and Paul John Nestel},
  journal={Arteriosclerosis},
  year={1990},
  volume={10 4},
  pages={582-90}
}
When human HepG2 hepatoma cells were pulsed with 125I-labeled high density lipoproteins (HDL) and chased in fresh medium, up to 65% of the radioactivity released was precipitable with trichloroacetic acid. Cell-internalized 125I-HDL contributed to the release of acid-precipitable material; when cells were treated with trypsin before the chase to remove 125I-HDL bound to the outer cell membrane, 50% of the released material was still acid-precipitable. Characterization of the radioactive… CONTINUE READING
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1 Excerpt

Blerman EL Binding of high density llpoproteins to cell receptors promotes translocation of cholesterol from intracellular membranes to the cell surface

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