Retrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxin.

@article{Wang2006RetrocyclinsKB,
  title={Retrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxin.},
  author={Wei Wang and Chandrika Mulakala and Sabrina C Ward and Grace New Westminster Jung and Hai Linh Luong and Duy M. Pham and Alan James Waring and Yiannis N. Kaznessis and Wuyuan Lu and Kenneth A. Bradley and Robert I. Lehrer},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 43},
  pages={
          32755-64
        }
}
Theta-defensins are cyclic octadecapeptides encoded by the modified alpha-defensin genes of certain nonhuman primates. The recent demonstration that human alpha-defensins could prevent deleterious effects of anthrax lethal toxin in vitro and in vivo led us to examine the effects of theta-defensins on Bacillus anthracis (Sterne). We tested rhesus theta-defensins 1-3, retrocyclins 1-3, and several analogues of RC-1. Low concentrations of theta-defensins not only killed vegetative cells of B… CONTINUE READING

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