Retroconversion is a minor contributor to increases in eicosapentaenoic acid following docosahexaenoic acid feeding as determined by compound specific isotope analysis in rat liver

@inproceedings{Metherel2017RetroconversionIA,
  title={Retroconversion is a minor contributor to increases in eicosapentaenoic acid following docosahexaenoic acid feeding as determined by compound specific isotope analysis in rat liver},
  author={Adam Henry Metherel and Rapha{\"e}l Chouinard-Watkins and Marc-Olivier Tr{\'e}panier and R J Scott Lacombe and Richard P. Bazinet},
  booktitle={Nutrition & Metabolism},
  year={2017}
}
Dietary docosahexaenoic acid (DHA, 22:6n-3) not only increases blood and tissue levels of DHA, but also eicosapentaenoic acid (EPA, 20:5n-3). It is generally believed that this increase is due to DHA retroconversion to EPA, however, a slower conversion of α-linolenic acid (ALA, 18:3n-3) derived EPA to downstream metabolic products (i.e. slower turnover of EPA) is equally plausible. In this study, 21-day old Long Evans rats were weaned onto an ALA only or DHA + ALA diet for 12 weeks. Afterwards… CONTINUE READING

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