Retrieval induces hippocampal-dependent reconsolidation of spatial memory.

  title={Retrieval induces hippocampal-dependent reconsolidation of spatial memory.},
  author={Janine Inez Rossato and L{\'i}a R. M. Bevilaqua and Jorge Horacio Medina and Ivan A. Izquierdo and Mart{\'i}n Cammarota},
  journal={Learning & memory},
  volume={13 4},
Nonreinforced retrieval can cause extinction and/or reconsolidation, two processes that affect subsequent retrieval in opposite ways. Using the Morris water maze task we show that, in the rat, repeated nonreinforced expression of spatial memory causes extinction, which is unaffected by inhibition of protein synthesis within the CA1 region of the dorsal hippocampus. However, if the number of nonreinforced retrieval trials is insufficient to induce long-lasting extinction, then a hippocampal… CONTINUE READING