Retrieval and reconsolidation: toward a neurobiology of remembering.

@article{Sara2000RetrievalAR,
  title={Retrieval and reconsolidation: toward a neurobiology of remembering.},
  author={Susan Sara},
  journal={Learning \& memory},
  year={2000},
  volume={7 2},
  pages={
          73-84
        }
}
  • S. Sara
  • Published 1 March 2000
  • Biology, Psychology
  • Learning & memory
Memory lends itself to study through its retrieval whether it is evaluated by the behavior of a mouse in a swimming pool, a verbal report from a human subject, or inferred from an electrophysiological event. As William James so aptly pointed out, “the only proof of there being retention is that recall actually takes place.” (1892). Such a view of memory as remembering is well elaborated in the theoretical reflections of Bergson (1896), in the seminal studies of Bartlett (1932) and later in… 

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References

SHOWING 1-10 OF 113 REFERENCES
Noradrenergic Modulation of Selective Attention: Its Role in Memory Retrieval
  • S. Sara
  • Psychology, Biology
    Annals of the New York Academy of Sciences
  • 1985
TLDR
It is argued that the context plays an essential role in memory retrieval processes and that memory dysfunction might involve deficits in contextual control of responding.
The hippocampus and contextual retrieval of information from memory: a theory.
  • R. Hirsh
  • Biology, Psychology
    Behavioral biology
  • 1974
Encoding specificity and retrieval processes in episodic memory.
TLDR
This paper describes and evaluates explanations offered by these theories to account for the effect of extralist cuing, facilitation of recall of list items by nonlist items.
Background stimuli as a reminder after spontaneous forgetting: Potentiation by stimulation of the mesencephalic reticular formation
TLDR
The results suggest that the stimulation acts to potentiate retrieval processes already triggered by the significant contextual cue reminder, which can be potentiated by a stimulation of the mesencephalic reticular formation.
Time-Dependent Processes in Memory Storage
TLDR
The findings indicate that the long-lasting trace of an experience is not completely fixed, consolidated, or coded at the time of the experience, and that any search for the engram or the basis of memory is not going to be successful.
Reconsolidation of memory after its reactivation
Contextual cues and memory retrieval in rats: Alleviation of forgetting by a pretest exposure to background stimuli
TLDR
It is shown that there must be a memory lapse before contextual cues can be demonstrated to be effective in facilitating memory retrieval, and a reminder which does not in itself contain sufficient information to facilitate performance of a naive animal significantly improves maze performance of animals which have “forgotten,” even on the first retention test.
Distributed Encoding and Retrieval of Spatial Memory in the Hippocampus
TLDR
Although spatial tasks can be acquired with local ensembles of hippocampal neurons when other parts of the hippocampus are inactivated, spatial memory is normally both encoded and retrieved by a widely distributed hippocampal network.
On the Transfer of Information from Temporary to Permanent Memory [and Discussion]
TLDR
It is argued that memory is largely a function of depth and elaboration of the initial encoding, and that the memory deficits found in elderly people and under conditions of divided attention reflect impaired comprehension of the material.
...
...