Retreatment with alteplase for early signs of reocclusion after thrombolysis. The European Cooperative Study Group.

@article{Simoons1993RetreatmentWA,
  title={Retreatment with alteplase for early signs of reocclusion after thrombolysis. The European Cooperative Study Group.},
  author={Maarten L. Simoons and J M M C Arnout and Marcel van den Brand and K N{\"y}ssen and Verstraete Verstraete},
  journal={The American journal of cardiology},
  year={1993},
  volume={71 7},
  pages={
          524-8
        }
}
Recurrent chest pain with new ST-segment elevation was observed in 26 of 652 patients (4%) with myocardial infarction in a clinical trial of alteplase (recombinant tissue-type plasminogen activator; 100 mg) and aspirin with or without heparin. Clinical and electrocardiographic signs of reocclusion were treated with a second dose of alteplase: 50 mg in 20 patients with signs of reocclusion < or = 24 hours after initial therapy, and 100 mg in 5 patients with signs between 24 and 77 hours, and in… CONTINUE READING

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