Retransplant candidates have donor-specific antibodies that react with structurally defined HLA-DR,DQ,DP epitopes.

@article{Duquesnoy2008RetransplantCH,
  title={Retransplant candidates have donor-specific antibodies that react with structurally defined HLA-DR,DQ,DP epitopes.},
  author={Ren{\'e} J. Duquesnoy and Yehia Awadalla and Jon Lomago and Larry Jelinek and Judy Howe and Dwayne Zern and Betty Hunter and J A Ortega Martell and Alin L Girnita and Adriana Zeevi},
  journal={Transplant immunology},
  year={2008},
  volume={18 4},
  pages={352-60}
}
This report describes a detailed analysis how donor-specific HLA class II epitope mismatching affects antibody reactivity patterns in 75 solid organ transplant recipients with an in situ allograft and who were considered for retransplantation. Sera were tested for antibodies in a sensitive antigen-binding assay (Luminex) with single class II alleles. Their reactivity was analyzed with HLAMatchmaker, a structural matching algorithm that considers so-called eplets to define epitopes recognized by… CONTINUE READING
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