Retracted: Effect of blonanserin on cognitive function in antipsychotic‐naïve first‐episode schizophrenia

@article{Tenjin2012RetractedEO,
  title={Retracted: Effect of blonanserin on cognitive function in antipsychotic‐na{\"i}ve first‐episode schizophrenia},
  author={Tomomi Tenjin and Seiya Miyamoto and Nobumi Miyake and Shin Ogino and Rei Kitajima and Kazuaki Ojima and Jun Arai and Haruki Teramoto and Sachiko Tsukahara and Yukie Ito and Masanori Tadokoro and Kiriko Anai and Yasuyuki Funamoto and Yasuhiro Kaneda and Tomiki Sumiyoshi and Noboru Yamaguchi},
  journal={Human Psychopharmacology: Clinical and Experimental},
  year={2012},
  volume={27}
}
The purpose of this study was to evaluate the effects of blonanserin, a novel antipsychotic, on cognitive function in first‐episode schizophrenia. 

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Evaluated efficacy and tolerability of blonanserin in patients with schizophrenia and delirium is found to be effective and well tolerated.

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Results suggest that blonanserin may be a promising candidate for a first-line antipsychotic for acute and maintenance therapy for schizophrenia.

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Although regulatory bodies have approved only a handful of antipsychotic drugs in recent years, the wide spectrum of targets that are being explored could eventually bring out antipsychotics with improved efficacy and acceptability, as well as the potential to revolutionize psychiatric practice.

Blonanserin Ameliorates Phencyclidine-Induced Visual-Recognition Memory Deficits: the Complex Mechanism of Blonanserin Action Involving D3-5-HT2A and D1-NMDA Receptors in the mPFC

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The results suggest that the ameliorating effect of blonanserin on PCP-induced cognitive impairment is associated with indirect functional stimulation of the dopamine-D1-PKA-NMDA receptor pathway following augmentation of dopaminergic neurotransmission due to inhibition of both dopamine- D3 and serotonin 5-HT2A receptors in the mPFC.

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