Retinoylation of the type II cAMP-binding regulatory subunit of cAMP-dependent protein kinase is increased in psoriatic human fibroblasts.

@article{Tournier1996RetinoylationOT,
  title={Retinoylation of the type II cAMP-binding regulatory subunit of cAMP-dependent protein kinase is increased in psoriatic human fibroblasts.},
  author={S Tournier and Fabrice Raynaud and Pascale Gerbaud and Suzanne M. Lohmann and Wayne B. Anderson and Dani{\`e}le Evain-Brion},
  journal={Journal of cellular physiology},
  year={1996},
  volume={167 2},
  pages={196-203}
}
Previously, we have reported a defect in the cAMP-dependent protein kinases (cAMP-PK) in psoriatic cells (i.e., a decrease in 8-azido-[32P]cAMP binding to the regulatory subunits and a decrease in phosphotransferase activity) which is rapidly reversed with retinoic acid (RA) treatment of these cells. This led us to examine a possible direct interaction between retinoids and the RI and RII regulatory subunits through retinoylation. Retinoylation of RI and RII present in normal and psoriatic… CONTINUE READING