Retinoschisin, a photoreceptor-secreted protein, and its interaction with bipolar and muller cells.

@article{Reid2003RetinoschisinAP,
  title={Retinoschisin, a photoreceptor-secreted protein, and its interaction with bipolar and muller cells.},
  author={Silvia N M Reid and Clyde Y Yamashita and Debora B Farber},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 14},
  pages={6030-40}
}
Usually, photoreceptors interact with other retinal cells through the neurotransmitter glutamate. Here we describe a nonsynaptic interaction via a secreted protein, retinoschisin. Using in situ hybridization, we found that from early postnatal life retinoschisin mRNA is present only in the outer retina of the mouse, and with single-cell RT-PCR we demonstrated its localization in rod and cone photoreceptor cells but not in Müller cells. Western blot analyses of proteins from cultured ocular… CONTINUE READING