Retinol uptake and metabolism, and cellular retinol binding protein expression in an in vitro model of hepatic stellate cells

@article{Vicente1998RetinolUA,
  title={Retinol uptake and metabolism, and cellular retinol binding protein expression in an in vitro model of hepatic stellate cells},
  author={Cristina Pontes Vicente and Vitor A. Fortuna and Rogerio Margis and Luiz Carlos Trugo and Radovan Borojevi{\'c}},
  journal={Molecular and Cellular Biochemistry},
  year={1998},
  volume={187},
  pages={11-21}
}
Liver is a major site of retinoid metabolism and storage, and more than 80% of the liver retinoids are stored in hepatic stellate cells. These cells represent less than 1% of the total liver protein, reaching a very high relative intracellular retinoid concentration. The plasma level of retinol is maintained close to 2 μM, and hepatic stellate cells have to be able both to uptake or to release retinol depending upon the extracellular retinol status. In view of their paucity in the liver tissue… CONTINUE READING