Retinol up-regulates the receptor for advanced glycation endproducts (RAGE) by increasing intracellular reactive species.

Retinol (vitamin A) and other retinoids have been suggested to exert an important antioxidant function in biological systems, besides their more established role as regulators of cell growth and differentiation. On the other hand, many authors have recently observed pro-oxidant activities of vitamin A and other retinoids in vitro and in vivo, resulting in… (More)