Retinol supplementation induces oxidative stress and modulates antioxidant enzyme activities in rat sertoli cells.

@article{DalPizzol2001RetinolSI,
  title={Retinol supplementation induces oxidative stress and modulates antioxidant enzyme activities in rat sertoli cells.},
  author={Felipe Dal-Pizzol and F{\'a}bio Klamt and Mara Silveira Benfato and Elena Aida Bernard and Jos{\'e} Cl{\'a}udio Fonseca Moreira},
  journal={Free radical research},
  year={2001},
  volume={34 4},
  pages={395-404}
}
Recent intervention studies revealed that supplementation with retinoids resulted in a higher incidence of lung cancer. Recently the causal mechanism has begun to be clarified. We report here that retinol caused cellular oxidative stress and modulated superoxide dismutase, catalase and glutathione peroxidase activities. Retinol (7 microM) significantly… CONTINUE READING