Retinol may promote fluorouracil-suppressed healing of experimental intestinal anastomoses.

  title={Retinol may promote fluorouracil-suppressed healing of experimental intestinal anastomoses.},
  author={Jan Willem D de Waard and Theo Wobbes and Cees J van der Linden and Thijs Hendriks},
  journal={Archives of surgery},
  volume={130 9},
OBJECTIVES To examine the effects of perioperative administration of fluorouracil on healing variables of internal anastomoses and to explore ways to promote repair under these conditions. DESIGN Seven-day, prospective randomized experimental trial. SETTING Animal research laboratory. ANIMALS Male young-adult Wistar rats after resection and anastomosis of both ileum and colon. INTERVENTIONS Random assignment to groups receiving placebo, daily fluorouracil (20 mg/kg per day… CONTINUE READING


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