Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells.

@article{Marchette2010RetinolD1,
  title={Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells.},
  author={Lea D. Marchette and Debra A. Thompson and Marina A Kravtsova and Thierry N Ngansop and Md Nawajes Ali Mandal and Anne Kasus-Jacobi},
  journal={Free radical biology & medicine},
  year={2010},
  volume={48 1},
  pages={16-25}
}
Mutations of the photoreceptor retinol dehydrogenase 12 (RDH12) gene cause the early onset retinal dystrophy Leber congenital amaurosis (LCA) by mechanisms not completely resolved. Determining the physiological role of RDH12 in photoreceptors is the focus of this study. Previous studies showed that RDH12, and the closely related retinol dehydrogenase RDH11, can enzymatically reduce toxic lipid peroxidation products such as 4-hydroxynonenal (4-HNE), in vitro. To explore the significance of this… CONTINUE READING