Retinol, vitamins A, C, and E and breast cancer risk: a meta-analysis and meta-regression

@article{Fulan2011RetinolVA,
  title={Retinol, vitamins A, C, and E and breast cancer risk: a meta-analysis and meta-regression},
  author={Hu Fulan and Jiang Changxing and Wang Yi Baina and Zhang Wencui and Ling Chunqing and W. Fan and Li Dandan and S. Dianjun and W. Tong and Pang Da and Zhao Yashuang},
  journal={Cancer Causes \& Control},
  year={2011},
  volume={22},
  pages={1383-1396}
}
ObjectiveTo comprehensively summarize the associations between retinol, vitamins A, C, and E and breast cancer, and quantitatively estimate their dose–response relationships.MethodsWe searched PubMed, Embase, and Cochrane databases (from January 1982 to 15 March 2011) and the references of the relevant articles in English with sufficient information to estimate relative risk or odds ratio and the 95% confidence intervals, and comparable categories of vitamins. Two reviewers independently… Expand
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TLDR
Large intakes of vitamin C or E did not protect women in this study from breast cancer; any benefit of vitamin A supplements may be limited to women with diets low in vitamin A. Expand
Intake of vitamins A, C, and E and postmenopausal breast cancer. The Iowa Women's Health Study.
TLDR
The association between dietary antioxidant vitamin intake and the risk of breast cancer was examined in a prospective study of 34,387 postmenopausal women in Iowa, and results provide little evidence that intake of these vitamins is associated with breast cancer risk. Expand
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Small, statistically nonsignificant reductions in risk were observed with increasing intake of dietary retinol, β-carotene, and vitamin C, but the magnitude of these associations was reduced after adjustment for other dietary factors. Expand
Vitamins A, C and E and the risk of breast cancer: results from a case-control study in Greece
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The inverse association observed with β- carotene intake is slightly weaker than the association previously observed with vegetable intake in these data, raising the possibility that the observed β-carotene effect is accounted for by another component of vegetables. Expand
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TLDR
The findings do not suggest a strong role, if any, for intake of vitamins C and E, beta-carotene, retinol, dietary fibre, vegetables, fruit and potatoes in the aetiology of breast cancer. Expand
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This analysis confirms the association between intake of vegetables and, to a lesser extent, fruits and breast cancer risk from published sources and suggests increasing vegetable consumption might reduce the risk of breast cancer. Expand
Intake of vitamins A, C, and E from diet and supplements and breast cancer in postmenopausal women
TLDR
Breast cancer was not significantly related to the intakes of vitamin A or E, whereas a monotonic dose–response relation was seen for the intake of vitamin C, and an increase in breast cancer rate with increasing intake. Expand
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BACKGROUND Observational studies suggested that a diet high in fruits and vegetables, both of which are rich with antioxidants, may prevent cancer development. However, findings from randomizedExpand
Dietary β-carotene, vitamin C and E intake and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Overall, dietary intake of β-carotene, vitamin C and E was not related to breast cancer risk in neither pre- nor postmenopausal women, and a weak protective effect between β- carotene and vitamin E from food and Breast cancer risk cannot be excluded. Expand
Fruits, vegetables, and micronutrients in relation to breast cancer modified by menopause and hormone receptor status.
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TLDR
An inverse association for fruit and vegetable intake among postmenopausal but not premenopausal breast cancer, which may be more pronounced among women with ER+ tumors is supported, but results were less consistent for micronutrients. Expand
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