Retinoids inhibit proliferation of human coronary smooth muscle cells by modulating cell cycle regulators.

@article{Wakino2001RetinoidsIP,
  title={Retinoids inhibit proliferation of human coronary smooth muscle cells by modulating cell cycle regulators.},
  author={Shu Wakino and Ulrich Kintscher and Sun-Mi Kim and Sue Jackson and F. Mei Yin and Sunil Nagpal and Roshantha A.S. Chandraratna and Willa A. Hsueh and Ronald E. Law},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2001},
  volume={21 5},
  pages={746-51}
}
Retinoids inhibit rat vascular smooth muscle cell (VSMC) proliferation in vitro and intimal hyperplasia in vivo. We examined the mechanism of the antiproliferative effect of retinoids on human coronary artery smooth muscle cells (human CASMCs). The RAR ligands all-trans-retinoic acid (atRA) and ethyl-p-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-l-propenyl]-benzoic acid (TTNPB); a pan-RXR/RAR agonist, 9-cis-retinoic acid (9cRA); and the RXR-selective ligand AGN4204 all inhibited… CONTINUE READING
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