Retinoids in the treatment of acute promyelocytic leukemia. Review of the literature.


Retinoids are derivates of vitamin A. They play an important role in embryogenesis and differentiation of normal cells. All-trans retinoic acid (ATRA, Tretinoin) and 13-cis retinoid acid (cRA, Isotretinoin) are the most important isomers. The first treatment with retinoids in a patient with an acute promyelocytic leukemia (APL) is reported in 1983. Since… (More)


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