Retinoids in cancer therapy and chemoprevention: promise meets resistance

@article{Freemantle2003RetinoidsIC,
  title={Retinoids in cancer therapy and chemoprevention: promise meets resistance},
  author={Sarah J. Freemantle and Michael J. Spinella and Ethan Dmitrovsky},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={7305-7315}
}
Retinoids (natural and synthetic derivatives of vitamin A) signal potent differentiation and growth-suppressive effects in diverse normal, premalignant, and malignant cells. A strong rationale exists for the use of retinoids in cancer treatment and chemoprevention based on preclinical, epidemiological, and early clinical findings. Despite the success of all-trans-retinoic acid (RA)-based differentiation therapy in acute promyelocytic leukemia (APL), the broad promise of retinoids in the clinic… CONTINUE READING

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