Retinoids are positive effectors of adipose cell differentiation.

  title={Retinoids are positive effectors of adipose cell differentiation.},
  author={Irina Safonova and Christian Darimont and Ez Z. Amri and Paola Grimaldi and G{\'e}rard Ailhaud and Uwe Reichert and Braham Shroot},
  journal={Molecular and cellular endocrinology},
  volume={104 2},
Retinoids, especially all-trans retinoic acid (t-RA), have been reported in the last decade to inhibit the differentiation of preadipose cells. In those studies, however, the concentrations of t-RA were supraphysiological (0.1-10 microM range). In contrast we show that, when present at concentrations below or close to the Kd values of retinoic acid receptors, retinoids behave as potent adipogenic hormones (1 pM to 10 nM range). As shown by the use of specific ligands for each RAR subtype, these… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 34 extracted citations

Similar Papers

Loading similar papers…