Retinoids and retinol differentially regulate steroid biosynthesis in ovarian theca cells isolated from normal cycling women and women with polycystic ovary syndrome.

@article{Wickenheisser2005RetinoidsAR,
  title={Retinoids and retinol differentially regulate steroid biosynthesis in ovarian theca cells isolated from normal cycling women and women with polycystic ovary syndrome.},
  author={Jessica K. Wickenheisser and Velen L. Nelson-DeGrave and Karen L Hendricks and Richard S Legro and Jerome F Strauss and J. M. McAllister},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2005},
  volume={90 8},
  pages={4858-65}
}
CONTEXT Polycystic ovary syndrome (PCOS) is characterized by ovarian androgen excess and infertility. Recent experiments have suggested that several genes involved in retinoic acid synthesis may be differentially expressed in PCOS theca cells and may contribute to excessive theca-derived androgen production. OBJECTIVE The study was performed to examine whether there are differential effects of retinol and retinoids on normal and PCOS theca cell function. DESIGN We used in vitro assays… CONTINUE READING

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