Retinoids and Cardiac Development

@inproceedings{Zaffran2014RetinoidsAC,
  title={Retinoids and Cardiac Development},
  author={St{\'e} phane Zaffran and Nicolas El Robrini and Nicolas Bertrand},
  year={2014}
}
Retinoic acid (RA), a derivative of vitamin A, is involved in signal transduction during vertebrate organogenesis. Retinoids through binding to nuclear receptors called RA receptors (RARs) and retinoid X receptors (RXRs) regulate various processes during cardiogenesis. Deregulated retinoid signaling thus has later consequences leading to cardiac malformations. In this review, we will summarize and discuss our current knowledge on the role of RA signaling during heart development, especially… CONTINUE READING

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