Retinoids Increase Lung Elastin Expression But Fail to Alter Morphology or Angiogenesis Genes in Premature Ventilated Baboons

@article{Pierce2007RetinoidsIL,
  title={Retinoids Increase Lung Elastin Expression But Fail to Alter Morphology or Angiogenesis Genes in Premature Ventilated Baboons},
  author={Richard A. Pierce and Belinda J Joyce and Susan M Officer and Catherine K Heintz and Carla L Moore and Donald C. McCurnin and Carl A. Johnston and William M. Maniscalco},
  journal={Pediatric Research},
  year={2007},
  volume={61},
  pages={703-709}
}
Retinoids regulate elastin synthesis by alveolar myofibroblasts and affect angiogenesis pathways, both of which are processes critical for alveolar development. Retinoids accelerate alveolarization in rodents and are now used therapeutically in premature infants at risk of bronchopulmonary dysplasia (BPD). This study examined the effects of retinoid supplementation on alveolar elastin expression and deposition and angiogenesis-related signaling in a primate model of BPD. Premature baboons… CONTINUE READING

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