Retinoids: potential in cancer prevention and therapy.

  title={Retinoids: potential in cancer prevention and therapy.},
  author={Nicole A Clarke and Pierre Germain and Lucia Altucci and Hinrich Gronemeyer},
  journal={Expert reviews in molecular medicine},
  volume={6 25},
Retinoids (derivatives of vitamin A) are signalling molecules that play important roles in cell growth, differentiation and death. Retinoids act through two types of receptors - retinoic acid receptors (RAR alpha, RAR beta and RAR gamma) and retinoid X receptors (RXR alpha, RXR beta and RXR gamma) - which themselves act as ligand-dependent transcription factors. Retinoids are of special interest in cancer research owing to their antiproliferative and cancer-preventative properties. They have… CONTINUE READING