Retinoids: compounds important to hair growth.

@article{Terezakis1988RetinoidsCI,
  title={Retinoids: compounds important to hair growth.},
  author={Nia K Terezakis and Gail S. Bazzano},
  journal={Clinics in dermatology},
  year={1988},
  volume={6 4},
  pages={
          129-31
        }
}

Effect of retinoids on follicular cells.

The additive effects of minoxidil and retinol on human hair growth in vitro.

It is found that the significant hair shaft elongation demonstrated after minoxidil plus retinol treatment would depend on the dual kinetics associated with the activations of Erk- and Akt-dependent pathways and the prevention of apoptosis by increasing the Bcl-2/Bax ratio.

Role of hormones in pilosebaceous unit development.

The biological and endocrinological basis of PSU development and the hormonal treatment of the PSU disorders hirsutism, acne vulgaris, and pattern alopecia are reviewed.

EEMCO Guidance for the Assessment of Hair Shedding and Alopecia

Clinical evaluations benefit from a few additional specific techniques that enhance the perception of hair (re-) growth, shedding and alopecia, especially when the hair loss is accompanied by scarring.

Experimental and early investigational drugs for androgenetic alopecia

It is proposed that topically applied medications, or intra-dermal injected or implanted materials, are preferable treatment modalities, minimizing side effect risks as compared to systemically applied treatments.

Promotive Effect of Topical Ketoconazole, Minoxidil, and Minoxidil with Tretinoin on Hair Growth in Male Mice

Topical use of 2% Ketoconazole solution has been reported to have a therapeutic effect on androgenic alopecia and Minoxidil was the most effective drug among them and demonstrated a significant stimulatory effect on hair growth compared with the control group.

The RAIG family member, GPRC5D, is associated with hard-keratinized structures.

The unique tissue distribution of GPRC5D indicates a relationship with hard keratins that constitute the major structural proteins of hard epithelial tissues, and analyses of cultured cells showed that transient overexpression resulted in suppression of Ha3 and stimulation of Ha4hair keratin gene expression, suggesting that this gene is regulated by a signal pathway different from that of hair keratin synthesis.

Sensitization to saw palmetto and minoxidil in separate topical extemporaneous treatments for androgenetic alopecia

We report a 24‐year‐old woman with androgenetic alopecia who became sensitized to topical minoxidil following use of an extemporaneous preparation of minoxidil 4% with retinoic acid in a propylene

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It has been shown that retinoids can exert effects on certain fully transformed, invasive, neoplastic cells, leading in certain instances to a suppression of proliferation and in other instances to terminal differentiation of these cells, resulting in a more benign, nonneoplastic pheno type.

Oral Retinoids in Dermatology

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Dermatology has a long-standing romance with vitamin A (retinoi) and the retinoids; as a topical agent, retinoic acid revolutionized the therapy of acne and related disorders.

Mechanism of action of retinoids.

Retinoids as preventive and therapeutic anticancer agents (Part I).

Ongoing in vitro studies of retinoid structure-activity relationships, effects on oncogene expression, reversal of drug-resistance, and, especially, the protein kinase-C cascade system should help clarify the precise mechanism of their anticancer action.

Monilethrix treated with the oral retinoid Ro 10‐9359 (Tigason)

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The prognosis is unpredictable, but generally the patients show increase in severity and extent throughout childhood, especially in those cases with alteration in hair type as the sole abnormality.

Topical minoxidil dose-response effect in alopecia areata.

A dose-response effect for topical minoxidil treatment of alopecia areata is strongly suggested and the importance of exploring modifications in dosing and delivery systems to enhance therapeutic efficacy is highlighted.

Tretinoin Therapy for Monilethrix

In the last few years, tretinoin has become a common therapeutic modality and its effectiveness has been proved in the treatment of a variety of different conditions such as acne comedonicus, psoriasis, lichen planus, and keratodermia.

The cutaneous safety of topical tretinoin.

Advances in the development of newer dosage forms and treatment regimens, together with expanded knowledge of the many factors which contribute to the problem, mean that there should be very few patients who cannot be treated with tretinoin.