Retinoid target gene activation during induced tumor cell differentiation: human embryonal carcinoma as a model.

@article{Spinella2003RetinoidTG,
  title={Retinoid target gene activation during induced tumor cell differentiation: human embryonal carcinoma as a model.},
  author={Michael J. Spinella and Joanna S Kerley and Kristina A White and Joshua C. Curtin},
  journal={The Journal of nutrition},
  year={2003},
  volume={133 1},
  pages={273S-276S}
}
Many agents that exhibit chemopreventive activity are able to mediate a differentiation response in premalignant and malignant tissues. One of the most widely studied classes of tumor differentiation agents is the retinoids. There is rapidly evolving evidence for beneficial retinoid actions in the prevention or treatment of clinical tumors. However, the use of retinoids in the clinic is limited by acquired resistance and toxicity, especially when administered chronically in preventive… CONTINUE READING

Citations

Publications citing this paper.

Similar Papers

Loading similar papers…