Retinoid supplementation of differentiating human neural progenitors and embryonic stem cells leads to enhanced neurogenesis in vitro.

@article{Christie2010RetinoidSO,
  title={Retinoid supplementation of differentiating human neural progenitors and embryonic stem cells leads to enhanced neurogenesis in vitro.},
  author={Victoria Buyers Christie and Daniel J Maltman and Andrew P. Henderson and Andrew Whiting and Todd B Marder and Majlinda Lako and Stefan Alexander Przyborski},
  journal={Journal of neuroscience methods},
  year={2010},
  volume={193 2},
  pages={239-45}
}
Retinoids are important molecules involved in the development and homeostasis of the nervous system. As such, various retinoid derivatives are often found in culture media and supplement formulations to support the growth and maintenance of neural cells. However, all-trans-retinoic acid (ATRA) and its associated derivatives are light sensitive and are highly susceptible to isomerisation. This can lead to variability in retinoid concentrations and the nature of the retinoid species present in… CONTINUE READING