Retinoid signaling in inner ear development: A "Goldilocks" phenomenon.

@article{Frenz2010RetinoidSI,
  title={Retinoid signaling in inner ear development: A "Goldilocks" phenomenon.},
  author={Dorothy A. Frenz and Wei Liu and Ales Cvekl and Qing Guo Xie and Lesley Wassef and Loredana Quadro and Karen Niederreither and Mark Maconochie and Alan Lawrence Shanske},
  journal={American journal of medical genetics. Part A},
  year={2010},
  volume={152A 12},
  pages={
          2947-61
        }
}
Retinoic acid (RA) is a biologically active derivative of vitamin A that is indispensable for inner ear development. The normal function of RA is achieved only at optimal homeostatic concentrations, with an excess or deficiency in RA leading to inner ear dysmorphogenesis. We present an overview of the role of RA in the developing mammalian inner ear, discussing both how and when RA may act to critically control a program of inner ear development. Molecular mechanisms of otic teratogenicity… CONTINUE READING

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Publications citing this paper.
SHOWING 1-10 OF 29 CITATIONS

A novel method for retinoic acid administration reveals differential and dose-dependent downregulation of Fgf3 in the developing inner ear and anterior CNS.

  • Developmental dynamics : an official publication of the American Association of Anatomists
  • 2012
VIEW 2 EXCERPTS
CITES RESULTS & BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 78 REFERENCES

Regulatory analysis of the mouse Fgf3 gene: control of embryonic expression patterns and dependence upon sonic hedgehog (Shh) signalling.

  • Developmental dynamics : an official publication of the American Association of Anatomists
  • 2004
VIEW 4 EXCERPTS

Retinoid signaling in inner ear development.

  • Journal of neurobiology
  • 2006
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1

M Studer, H Papperl, H Marshall, A Kuroiwa, R. Krumlauf
  • Science 265:1728–1732.
  • 1994
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Retinoic acid embryopathy.

  • The New England journal of medicine
  • 1985
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Requirements for FGF 3 and FGF 10 during inner ear formation

Y Alvarez, MT Alonso, +7 authors T Schimmang
  • 2003
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL