Retinoid-resistant estrogen receptor-negative human breast carcinoma cells transfected with retinoic acid receptor-alpha acquire sensitivity to growth inhibition by retinoids.

@article{Sheikh1994RetinoidresistantER,
  title={Retinoid-resistant estrogen receptor-negative human breast carcinoma cells transfected with retinoic acid receptor-alpha acquire sensitivity to growth inhibition by retinoids.},
  author={Mohmad Shafi Sheikh and Z M Shao and Xuewei Serene Li and Marcia I. Dawson and Anton M Jetten and Song Wu and Barbara A. Conley and Marcel Garcia and Henri Rochefort and Joseph A. Fontana},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 34},
  pages={21440-7}
}
Retinoids mediate their actions via RARs (retinoic acid receptors) and RXRs (retinoid X receptors). Each class of these nuclear retinoid receptors is further subdivided into three species, namely alpha, beta, and gamma. Recent studies demonstrate that estrogen receptor (ER)-positive human breast carcinoma (HBC) cell lines and tumor samples exhibit significantly higher levels of RAR alpha than their ER-negative counterparts. ER-positive HBC cell lines are sensitive to, and ER-negative cell lines… CONTINUE READING
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