Retinoid resistance in acute promyelocytic leukemia: new mechanisms, strategies, and implications.

  title={Retinoid resistance in acute promyelocytic leukemia: new mechanisms, strategies, and implications.},
  author={Raymond P. Warrell},
  volume={82 7},
EOPLASTIC CELLS, through their various stages of N growth and differentiation, develop a certain imperviousness to the various environmental, immunologic, toxicologic, and pharmacologic onslaughts to which they are subjected. A general example of this problem is expression of multidrug resistance wherein the activity of a glycoprotein pump responsible for efflux of toxins from the cell is increased, causing relative cross-resistance to a broad spectrum of compounds including anthracyclines… CONTINUE READING


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