Retinoid repletion of vitamin A-deficient mice restores IgG responses.

  title={Retinoid repletion of vitamin A-deficient mice restores IgG responses.},
  author={Tae Yong Chun and Julie A. Carman and Colleen Hayes},
  journal={The Journal of nutrition},
  volume={122 5},
Vitamin A-deficient (A-) mice produce poor IgG antibody responses due to a helper T cell dysfunction. We performed retinoid repletion studies to determine the minimum dietary retinyl acetate dose and the most active retinoid for supporting immune function. Dietary retinyl acetate repletion at 2 (R2 group) or 4 (R4 group) microgram/g diet restored serum retinol in A- mice to vitamin A-sufficient (A+) control levels within 24 h. However, in R4 mice, liver retinyl palmitate was restored about… CONTINUE READING

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