Retinoid-related receptor (ROR) α mRNA expression is altered in the brain of male mice lacking all ligand-binding thyroid hormone receptor (TR) isoforms

@article{Vasudevan2005RetinoidrelatedR,
  title={Retinoid-related receptor (ROR) α mRNA expression is altered in the brain of male mice lacking all ligand-binding thyroid hormone receptor (TR) isoforms},
  author={Dr. Nandini Vasudevan and Hosein Kami Kia and Maria M Hadjimarkou and Noriyuki Koibuchi and William Wei Lim Chin and Douglas Forrest and Bjorn Vennstrom and Donald D Pfaff},
  journal={Endocrine},
  year={2005},
  volume={26},
  pages={25-32}
}
In the vertebrate brain, the thalamus serves as a relay and integration station for diverse neuronal information en route from the periphery to the cortex. Deficiency of TH during development results in severe cerebral abnormalities similar to those seen in the mouse when the retinoic acid receptor (ROR)α gene is disrupted. To investigate the effect of the thyroid hormone receptors (TRs) on RORα gene expression, we used intact male mice, in which the genes encoding the α and β TRs have been… CONTINUE READING
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