Retinoid-related orphan receptors (RORs): roles in cell survival, differentiation and disease

@article{Jetten2002RetinoidrelatedOR,
  title={Retinoid-related orphan receptors (RORs): roles in cell survival, differentiation and disease},
  author={Anton M Jetten and Emi Ueda},
  journal={Cell Death and Differentiation},
  year={2002},
  volume={9},
  pages={1167-1171}
}
Nuclear receptors constitute a superfamily of ligand-dependent transcription factors, that include receptors for steroid hormones, retinoids, thyroid hormone, and eicosanoid metabolites, and orphan receptors for which the ligand has not yet been identified. The retinoid-related orphan receptors alpha, beta and gamma (RORa, b, and g also referred to as NR1F1 to -3, respectively) comprise a distinct subfamily of nuclear receptors. RORs share a modular structure composed of an amino terminal… CONTINUE READING