Retinoid-related orphan receptor gamma t is a potential therapeutic target for controlling inflammatory autoimmunity.

@article{Huang2007RetinoidrelatedOR,
  title={Retinoid-related orphan receptor gamma t is a potential therapeutic target for controlling inflammatory autoimmunity.},
  author={Zhaofeng Huang and Huimin Xie and Ruiqing Wang and Zuoming Sun},
  journal={Expert opinion on therapeutic targets},
  year={2007},
  volume={11 6},
  pages={737-43}
}
Retinoid-related orphan receptor gamma t (RORgamma t) is a member of the nuclear receptor family that is specifically expressed in T cell compartments. RORgamma t regulates the development of T cells in the thymus and the differentiation of effector T cells in the periphery. During T cell development, RORgamma t enhances CD4(+)CD8(+) double positive thymocyte survival by upregulating Bcl-x(L). In the periphery, RORgamma t regulates IL-17 production and dictates the differentiation of pro… CONTINUE READING
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