Retinoid regulation of the zebrafish cyp26a1 promoter.

  title={Retinoid regulation of the zebrafish cyp26a1 promoter.},
  author={Ping Hu and Miao Tian and Jie Bao and Guangdong Xing and Xingxing Gu and Xiang Gao and Elwood Linney and Qingshun Zhao},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  volume={237 12},
Cyp26A1 is a major enzyme that controls retinoic acid (RA) homeostasis by metabolizing RA into bio-inactive metabolites. Previous research revealed that the mouse Cyp26A1 promoter has two canonical RA response elements (RAREs) that underlie the regulation of the gene by RA. Analyzing the 2,533-base pairs (2.5 k) genomic sequence upstream of zebrafish… CONTINUE READING