Retinoid receptors in health and disease: co-regulators and the chromatin connection.

@article{Minucci1999RetinoidRI,
  title={Retinoid receptors in health and disease: co-regulators and the chromatin connection.},
  author={Saverio Minucci and Pier Giuseppe Pelicci},
  journal={Seminars in cell & developmental biology},
  year={1999},
  volume={10 2},
  pages={215-25}
}
Retinoid receptors behave as ligand-dependent transcriptional regulators, repressing transcription in the absence of ligand and activating transcription in its presence. The different effects on transcription are carried out through recruitment of co-regulators: unliganded receptors bind corepressors (NCoR and SMRT) that are found within a complex containing histone deacetylase (HDAC) activity, whereas liganded receptors recruit coactivators with histone acetylase activity (HATs). Chromatin… CONTINUE READING

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