Retinoid receptors and the induction of apoptosis in canine osteosarcoma cells.

@article{Hong2000RetinoidRA,
  title={Retinoid receptors and the induction of apoptosis in canine osteosarcoma cells.},
  author={S H Hong and Emi Ohashi and Tsuyoshi Kadosawa and Manabu Mochizuki and Satoru Matsunaga and Ryohei Nishimura and Nobuo Sasaki},
  journal={The Journal of veterinary medical science},
  year={2000},
  volume={62 4},
  pages={469-72}
}
Retinoids, all-trans-retinoic acid (ATRA) and 9-cis-retinoic acid (9-cis-RA), induced morphological changes and apoptosis-like cell death characterized by cell shrinkage, chromatin condensation and nuclear disintegration in three canine osteosarcoma cells, OOS, HOS and POS, at a concentration of 10(-5) M. Both retinoid receptors, RARs and RXRs, were identified in these cells. 9-cis-RA bound to both the RXRs and the RARs, whereas ATRA bound to only the RARs in these cells. Those results indicate… CONTINUE READING