Retinoid receptor cross-talk in respiratory epithelium cancer chemoprevention.

  title={Retinoid receptor cross-talk in respiratory epithelium cancer chemoprevention.},
  author={Michalis V Karamouzis and Athanasios G. Papavassiliou},
  journal={Trends in molecular medicine},
  volume={11 1},
The rationale for using retinoids in the prevention of respiratory epithelium cancers is based on their ability to coordinately regulate differentiation, proliferation and apoptosis. The complex retinoid signaling pathways and their cross-reactions are modulated by multiple mechanisms that are gradually being elucidated. It is possible that significant molecular changes take place during the very early stages of respiratory epithelial carcinogenesis, which enable cancer cells to escape… CONTINUE READING


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