Retinoid protects rats against neutrophil-induced oxidative stress in acute experimental mastitis.

@article{Gu2009RetinoidPR,
  title={Retinoid protects rats against neutrophil-induced oxidative stress in acute experimental mastitis.},
  author={Beibei Gu and Yu-min Zhu and Wei Zhu and Jinfeng Miao and Yu'e Deng and Sixiang Zou},
  journal={International immunopharmacology},
  year={2009},
  volume={9 2},
  pages={223-9}
}
Activated polymorphonuclear neutrophilic leukocytes (PMN) are able to produce large quantities of bactericidal molecules such as reactive oxygen species (ROS) that are associated with tissue damage in models of inflammatory mastitis. In this study, the putative protective effect of retinoid was evaluated in a lipopolysaccharide (LPS) induced mastitis model in rats. Commencing at 10 d of gestation, retinoid (dissolved in olive oil) or an equal volume of olive oil were administered daily by… CONTINUE READING
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