Retinoid prevents transformation of cultured mammary glands by procarcinogens but not by many activated carcinogens

@article{Dickens1980RetinoidPT,
  title={Retinoid prevents transformation of cultured mammary glands by procarcinogens but not by many activated carcinogens},
  author={Michael S. Dickens and Sam Sorof},
  journal={Nature},
  year={1980},
  volume={285},
  pages={581-584}
}
Specific hormones1,2 in concert with epidermal growth factor3 induce the mouse mammary gland in serum-free whole organ culture to undergo two physiological cycles3, each consisting of lobuloalveolar development, differentiation and involution (regression). In addition, chemical carcinogens cause an epithelial transformation, which is operationally defined by the presence of nodule-like alveolar lesions that have escaped the hormonal controls of lobuloalveolar development4–9. The transformed… CONTINUE READING

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