Retinoid-induced bone thinning is caused by subperiosteal osteoclast activity in adult rodents.

@article{Kneissel2005RetinoidinducedBT,
  title={Retinoid-induced bone thinning is caused by subperiosteal osteoclast activity in adult rodents.},
  author={Michaela Kneissel and Anne Studer and Reto Cortesi and Mira Susa},
  journal={Bone},
  year={2005},
  volume={36 2},
  pages={202-14}
}
Excess of Vitamin A (retinol) and related compounds (retinoids) induces bone fragility and is associated with increased hip fracture incidence in humans. Yet, their impact on the adult skeleton has been studied in relatively little detail. It is assumed that they induce generalized bone loss and decrease long-bone thickness due to reduction of radial bone growth. Here we characterized early skeletal responses of adult rodents to retinoid treatment, revealing novel aspects of retinoid action on… CONTINUE READING
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