Retinoid-induced apoptosis in normal and neoplastic tissues

  title={Retinoid-induced apoptosis in normal and neoplastic tissues},
  author={L{\'a}szl{\'o} Nagy and Vilmos A. Thomazy and Richard A. Heyman and Peter Davies},
  journal={Cell Death and Differentiation},
Vitamin A and its derivatives (collectively referred to as retinoids) are required for many fundamental life processes, including vision, reproduction, metabolism, cellular differentiation, hematopoesis, bone development, and pattern formation during embryogenesis. There is also considerable evidence to suggest that natural and synthetic retinoids have therapeutical effects due to their antiproliferative and apoptosis-inducing effects in human diseases such as cancer. Therefore it is not… CONTINUE READING