Retinoid-dependent growth inhibition, differentiation and apoptosis in acute promyelocytic leukemia cells. Expression and activation of caspases

@article{Giann2000RetinoiddependentGI,
  title={Retinoid-dependent growth inhibition, differentiation and apoptosis in acute promyelocytic leukemia cells. Expression and activation of caspases},
  author={M Giann{\`i} and I Ponzanelli and Luca Mologni and Uwe Reichert and Alessandro Rambaldi and Mineko Terao and Enrico Garattini},
  journal={Cell Death and Differentiation},
  year={2000},
  volume={7},
  pages={447-460}
}
In the NB4 model of acute promyelocytic leukemia (APL), ATRA, 9-cis retinoic acid (9-cis RA), the pan-RAR and RARα-selective agonists, TTNPB and AM580, induce growth inhibition, granulocytic differentiation and apoptosis. By contrast, two RXR agonists, a RARβ agonist and an anti-AP1 retinoid have very limited activity, ATRA- and AM580-dependent effects are completely inhibited by RAR antagonistic blockade, while 9-cis RA-induced cell-growth-inhibition and apoptosis are equally inhibited by RAR… CONTINUE READING

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