Retinoid X receptor and retinoic acid response in the marine sponge Suberites domuncula.

  title={Retinoid X receptor and retinoic acid response in the marine sponge Suberites domuncula.},
  author={Matthias Wiens and Renato Batel and Michael Korzhev and Werner E G M{\"u}ller},
  journal={The Journal of experimental biology},
  volume={206 Pt 18},
To date no nuclear receptors have been identified or cloned from the phylogenetically oldest metazoan phylum, the Porifera (sponges). We show that retinoic acid causes tissue regression in intact individuals of the demosponge Suberites domuncula and in primmorphs, special three-dimensional cell aggregates. Primmorphs were cultivated on a galectin/poly-L-lysine matrix in order to induce canal formation. In the presence of 1 or 50 micromol l(-1) retinoic acid these canals undergo regression, a… CONTINUE READING
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