Retinoid-X-receptor-alpha-independent binding of vitamin D receptor to its response element from human osteocalcin gene.

We have studied the role of retinoid X receptor alpha (RXR alpha) in vitamin D receptor (VDR) responsive interactions using nuclear extracts from human osteoblast-like MG-63 osteosarcoma cells and its specific response element from human osteocalcin gene (OC-VDRE). An RXR alpha-specific antibody was not capable of recognizing the two VDR responsive… CONTINUE READING