Retinoid X receptor agonists impair arterial mononuclear cell recruitment through peroxisome proliferator-activated receptor-γ activation.

@article{Sanz2012RetinoidXR,
  title={Retinoid X receptor agonists impair arterial mononuclear cell recruitment through peroxisome proliferator-activated receptor-γ activation.},
  author={Mar{\'i}a Jes{\'u}s Gil Sanz and Fernando Albertos and Eduardo Otero and Marina Juez and Esteban Jes{\'u}s Morcillo and Laura Piqueras},
  journal={Journal of immunology},
  year={2012},
  volume={189 1},
  pages={411-24}
}
Mononuclear cell migration into the vascular subendothelium constitutes an early event of the atherogenic process. Because the effect of retinoid X receptor (RXR)α on arterial mononuclear leukocyte recruitment is poorly understood, this study investigated whether RXR agonists can affect this response and the underlying mechanisms involved. Decreased RXRα expression was detected after 4 h stimulation of human umbilical arterial endothelial cells with TNF-α. Interestingly, under physiological… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…