Retinoic acid up-regulates erythropoietin production in hepatoma cells and in vitamin A-depleted rats.

@article{Okano1994RetinoicAU,
  title={Retinoic acid up-regulates erythropoietin production in hepatoma cells and in vitamin A-depleted rats.},
  author={Masamitsu Okano and Sonoko Masuda and Hiroshi Narita and Shoichi Masushige and Shigeaki Kato and Shogo Imagawa and Ryuzo Sasaki},
  journal={FEBS letters},
  year={1994},
  volume={349 2},
  pages={229-33}
}
Retinoic acid (RA) stimulated the production of erythropoietin (Epo) in a human hepatoma cell line, HepG2 cells. The stimulation was due to the accumulation of Epo mRNA. The Epo production in HepG2 cells was also dependent on O2 tension for cell culture but the enhancement of Epo production by RA was independent of O2 tension, indicating that RA exerts its effect through a pathway different from O2. Oral administration of RA to the vitamin A-depleted rats elevated the concentration of Epo in… CONTINUE READING

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