Retinoic acid stimulation of the human surfactant protein B promoter is thyroid transcription factor 1 site-dependent.

@article{Naltner2000RetinoicAS,
  title={Retinoic acid stimulation of the human surfactant protein B promoter is thyroid transcription factor 1 site-dependent.},
  author={Angela Naltner and Manely Ghaffari and Jeffrey A. Whitsett and C. W. Yan},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 1},
  pages={56-62}
}
Surfactant B (SP-B) is a 79-amino acid peptide critical to postnatal respiratory adaptation. Expression of SP-B by respiratory epithelial cells is regulated by developmental and hormonal influences at the level of gene transcription. Previous studies supported the role of retinoic acids (RA) and their receptors (RARs) in SP-B gene transcription. In the present study, RARalpha was detected in mouse alveolar type II epithelial cells where SP-B is synthesized and processed. Deletion and site… CONTINUE READING

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RAR, and Coactivator Stimulation of the hSP-B Gene

  • N. Moghal, B. G. Neel
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  • 1998
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