Retinoic acid stimulates myocardial expansion by induction of hepatic erythropoietin which activates epicardial Igf2.

  • Thomas Brade, Sandeep Kumar, +7 authors Gregg Duester
  • Published 2011 in Development

Abstract

Epicardial signaling and Rxra are required for expansion of the ventricular myocardial compact zone. Here, we examine Raldh2(-/-) and Rxra(-/-) mouse embryos to investigate the role of retinoic acid (RA) signaling in this developmental process. The heart phenotypes of Raldh2 and Rxra mutants are very similar and are characterized by a prominent defect in… (More)
DOI: 10.1242/dev.054239

Cite this paper

@article{Brade2011RetinoicAS, title={Retinoic acid stimulates myocardial expansion by induction of hepatic erythropoietin which activates epicardial Igf2.}, author={Thomas Brade and Sandeep Kumar and Thomas Cunningham and Christina Chatzi and Xianling Zhao and Susana Cavallero and Peng Li and Henry M Sucov and Pilar Ruiz-Lozano and Gregg Duester}, journal={Development}, year={2011}, volume={138 1}, pages={139-48} }